1241-1243 Peng LAJP 3359:Peng
نویسندگان
چکیده
Herb-drug interaction strongly limits the clinical utilization of herbs and synthetic drugs. The inhibition of drug metabolism has been widely accepted to be an important reason for herb-drug interaction. The present study aims to investigate the inhibitory potential of herbal component scutellarein towards the metabolism of AZT which is the first U.S. government-approved antiretroviral drug for the successful treatment for the HIV/AIDS infectiousness, trying to predict potential scutellarein-AZT interaction. Noncompetitive inhibition of scutellarein towards AZT metabolism was demonstrated with the inhibition kinetic parameter (Ki) to be 19.6 μM. In vivo scutellarein-AZT interaction seems not to occur in vivo maximum plasma concentration (Cmax) after administration of 400 mg/kg scutellarin for rat. However, due to the complex factors affecting the in vitro-in vivo extrapolation (IV-IVE), the translation from in vitro data to in vivo situation should be given much attention.
منابع مشابه
a sequential formulation for compositional reservoirs simulation using peng robinson equation of state
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